Columbia University, Postdoctoral, 2018, Biology
University of Georgia, Ph.D., 2013, Neuroscience
University of Georgia, M.S., 2010, Psychology
University of Georgia, B.A., 2008, Philosophy
Schizophrenia, Neural Circuits, Interneurons, Sensory processing, Neural oscillations, Two-photon calcium imaging
Jordan Hamm completed his Ph.D. in neuroscience at the University of Georgia from 2008 to 2013 under the mentorship of Dr. Brett Clementz. Here he studied human populations with bipolar disorder and SZ, carrying out electro/magnetoencephalography (E/MEG) and multivariate analyses (K-means, PCA, Joint-ICA) of large multimodal datasets (MRI, EEG, genetics, behavior). Findings from this work emphasized the utility of studying neuroimaging “biomarkers” as translational and quantitative tools for the revision of diagnostic categories in psychiatry. To investigate the biological mechanisms of these biomarkers, Dr. Hamm started a postdoctoral position in Rafael Yuste’s laboratory at Columbia University in 2014, where he transitioned to studying cortical function with cellular precision in awake mice. Dr. Hamm was trained in two-photon calcium imaging (2P-Ca++), opto/chemicogenetics, and multi-electrode recordings, and developed his own research program aimed at mapping specific domains of dysfunction in a psychiatric population (i.e. sensory processing dysfunction) from biomarkers and behaviors to cells and circuits.
The Hamm lab conducts basic research on the mammalian cerebral cortex, focusing on how neural circuits process sensory inputs and integrate this information with past experience, predictions, and behavioral goals. His laboratory employs techniques such as 2P-Ca++, dense array local field potential recordings (LFP/CSD), and opto/chemicogenetics in awake, behaving mice, utilizing both wild-type mice and mouse models of SZ-relevant disease processes. Critically, sensory cortical structure and function is relatively well-conserved across mammals, and is highly accessible with classic psychophysical and neuroscience approaches. The Hamm lab takes advantage of this fact, utilizing paradigms which can be employed with human patients in clinical settings and rodent models in the lab, whereby established disease “biomarkers” (e.g. EEG measures) can be linked with specific neurobiology and therapeutics.
Visit Dr. Hamm's, Google Scholar page to see his entire publications.
- VBastos, B., Holmes, J., Ross, J.M., Rader, A.M., Gallimore, C.G., Wargo, J.A., Peterka, D.S., Hamm. J.P. Top-down input modulates visual context processing through an interneuron-specific circuit. Cell Reports—accepted. In press. preprint at BioRxiv - DOI: https://doi.org/10.1101/2023.02.25.53004
- Van Derveer, A., Ross, J.M., Hamm. J.P. (2023) Robust multisensory deviance detection in the mouse parietal associative area. Current Biology. In press. DOI: https://doi.org/10.1016/j.cub.2023.08.002
- Gallimore, C.G., Ricci, D., Hamm. J.P. (2023) Spatiotemporal dynamics across a neocortical column support a predictive coding framework for interpreting visual mismatch responses. Cerebral Cortex. 33(15): 9417–9428. DOI: https://doi.org/10.1093/cercor/bhad215
- Hamm, J.P., Shymkiv, Y., Han, S., Yang, W. Yuste, R. Cortical ensembles selective for context. (2021). Proceedings of the National Academy of Sciences of the United States of America (PNAS). 118(14):e2026179118. DOI: https://doi.org/10.1073/pnas.2026179118.
- Van Derveer, A.B, Bastos, G, Ferrell. A.D., Gallimore, C.G., Greene, M.L., Holmes, J.T., Kubricka, V., Ross, J.M., Hamm, J.P. (2020) A role for somatostatin-positive interneurons in neuro-oscillatory and information processing deficits in schizophrenia. Schizophrenia Bulletin. DOI: https://doi.org/10.1093/schbul/sbaa184
- Wenzel, M., Hamm, J.P. (2020) Identification and quantification of neuronal ensembles in optical imaging experiments. Journal of Neuroscience Methods. 351, 109046. DOI: https://doi.org/10.1016/j.jneumeth.2020.109046
- Ross, J.M., Hamm, J.P. (2020) Cortical Microcircuit Mechanisms of Mismatch Negativity and Its Underlying Subcomponents. Front Neural Circuits. 14:13. DOI: https://doi.org/10.3389/fncir.2020.00013
- Hamm, J.P., Shymkiv, Y., Gogos, J.A., Yuste, R. (2020). Aberrant cortical ensembles and schizophrenia-like sensory phenotypes in setd1a mice. Biological Psychiatry. 88(3):215-223. DOI: https://doi.org/10.1016/j.biopsych.2020.01.004
- Hamm, J.P., Peterka, D.S., Gogos, J.A., Yuste, R. (2017) Altered cortical ensembles in mouse models of schizophrenia. Neuron. 94, 1, 153–167. DOI: https://doi.org/10.1016/j.neuron.2017.03.019.
- Hamm, J.P., Yuste, R. (2016). Somatostatin Interneurons Control a Key Component of Mismatch Negativity in Mouse Visual Cortex. Cell Reports. 16, 407–420. DOI: https://doi.org/10.1016/j.celrep.2016.06.037.
- Hamm, J.P., Dyckman, K.A., McDowell, J.E., Clementz, B.A. (2012) Pre-cue Fronto-Occipital Alpha Phase and Distributed Cortical Oscillations Predict Failures of Cognitive Control. Journal of Neuroscience. 32(20):7034-41. DOI: https://doi.org/10.1523/JNEUROSCI.5198-11.2012.
- Hamm, J.P., Gilmore, C.S., Picchetti, N, Sponheim, S.R., and Clementz, B.A. (2011). Abnormalities of Neuronal Oscillations and Temporal Integration to Low and High Frequency Auditory Stimulation in Schizophrenia. Biological Psychiatry. 69(10):989-96. DOI: https://doi.org/10.1016/j.biopsych.2010.11.021.