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Binghe Wang

Professor, Regents    Georgia Research Alliance Eminent Scholar in Drug Discovery, and Associate Dean for Natural and Computational Sciences
Education

BS, Medicinal Chemistry, Beijing Medical College, 1982
Ph.D. Dept. of Medicinal Chemistry, University of Kansas, 1991
Postdoc: Dept. of Chemistry, University of Arizona, 1992
Postdoc: Dept. of Pharmaceutical Chemistry, University of Kansas,1993

Specializations

Organic Chemistry, Medicinal Chemistry, Biochemistry, Analytical Chemistry

Biography

Dr. Binghe Wang serves as the Associate Dean for the Natural and Computational Sciences area for the College of Arts and Sciences. He is Regents’ Professor of Chemistry, Georgia Research Alliance Eminent Scholar in Drug discovery, and Georgia Cancer Coalition Distinguished Cancer Scholar.

Research Interest:
(1) Drug Design: anticancer, anti-infectives, anti-inflammation, immune regulation; (2) Drug delivery: prodrug, receptor-mediated drug delivery, drug-release chemistry; (3) New diagnostics, fluorescent sensors, and molecular probes; (4) Disease biomarkers including carbohydrate biomarkers

Binghe Wang was born in 1962 in Beijing, China. In 1966, at the beginning of the so-called Cultural Revolution, his whole family was sent to the countryside in Hebei Province. Therefore, he spent his formative years interacting with people who were not the most fortunate, but maintained some of the most optimistic views on life. The hard life in the countryside taught him many lessons that proved very useful later on in life. In 1978 when China re-opened its universities, he was admitted into Beijing Medical College (now Beijing University Health Sciences Center) where he met his wife, Siming. After receiving his B.S. degree in Medicinal Chemistry, he started his graduate career first at the University of British Columbia, Department of Chemistry. Still longing for a career in medicinal chemistry, he later transferred to the University of Kansas, which has one of the best medicinal chemistry programs in the world. While at the University of Kansas working under the guidance of the late Professor Matt Mertes and Professor Kristin Bowman-James, he studied thymidylate synthase, a target enzyme for cancer chemotherapy, and the design and synthesis of molecular catalysts. After receiving his Ph.D. degree, he worked with Professors Victor Hruby at the University of Arizona and Ronald T. Borchardt at the University of Kansas before embarking on his own independent academic career in 1994 at the University of Oklahoma College of Pharmacy as an assistant professor of medicinal chemistry. In 1996, he moved to North Carolina State University as an assistant professor of chemistry. In 2003, he assumed the position of Professor and Georgia Research Alliance Eminent Scholar in Drug Discovery at Georgia State University. He is the Editor-in-Chief of Medicinal Research Reviews and book series editor of “A Wiley Series in Drug Discovery and Development.” In addition, he has edited two books together with his colleagues: “Drug Delivery: Principles and Applications” published by John Wiley and Sons and “Pharmaceutical Profiling in Drug Discovery for Lead Selection” published by the American Association of Pharmaceutical Scientists.

Outside of chemistry and drug discovery, he enjoys fishing (although he does not get much time to do it often), traveling, friends, and most of all spending time with his family, who help to keep his life balanced.

CV – Dr. Binghe Wang

Publications

Representative Publications

  1. Dai, C.; Cazares, L.H.; Wang, L.; Chu, Y.; Troyer, D.A.; Semmes, O.J.; Drake, R.R. Wang, B. Using boronolectin in MALDI-MS imaging for the histological analysis of cancer tissue expressing the sialyl Lewis X antigen. Chem. Commun. 2011, 47, 10338-10340.
  2. Chen, W.; Wang, D.; Dai, C.; Hamelberg, D. Wang, B. Clicking 1,2,4,5-tetrazine and cyclooctynes with tunable reaction rates. Chem. Commun. 2012, 48, 1736-1738.
  3. Peng, H.; Cheng, Y.; Dai, C.; Wang, B. A Fluorescent Probe for Fast and Quantitative Detection of Hydrogen Sulfide in Blood. Angew. Chem. Int. Ed. 2011, 50, 9672-9675.
  4. Ke, B.; Chen, W.; Ni, N.; Cheng, Y.; Dihn, H.; Dai, C.; Wang, B. “A Fluorescent Probe for Rapid Aqueous Fluoride Detection and Cell Imaging” Chem. Commun. 2013, 49, 2579-2580.
  5. Cui, J.; Jin, J.; Hsieh, Y.; Yang, H.; Ke, B.; Tai, P.S.; Wang, B. “Water-soluble Fluorescent Boronic Acid Compounds for Saccharide Sensing: Structural Effect on Their Fluorescence Properties” ChemMedChem, 2013, 8, 1384-1393